GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2243480 | 1 | rs11538349 | chr7:65421871 | CCT6P1 | chr7:65216092-65228661:+ | 0.33 | 7.3 | 5.42E-13 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs11538349 | chr7:65421871 | LOC493754 | chr7:65993446-66057363:- | 0.21 | 3.62 | 0.000305 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs11538349 | chr7:65421871 | ZNF117 | chr7:64434830-64467121:- | -0.26 | -4.86 | 1.37E-6 | Diabetic kidney disease |
| BRCA | cis | rs12748152 | 1 | rs11538549 | chr1:27248283 | GPATCH3 | chr1:27216980-27226962:- | 0.23 | 3.83 | 0.000136 | HDL cholesterol;Triglycerides;LDL cholesterol |
| BRCA | cis | rs1789924 | 1 | rs1154435 | chr4:100285148 | ADH1C | chr4:100257651-100273917:- | -0.21 | -6.67 | 4.1E-11 | Oral cavity and pharyngeal cancer |
| BRCA | cis | rs1789924 | 1 | rs1154435 | chr4:100285148 | ADH4 | chr4:100044835-100065449:- | -0.11 | -3.38 | 0.000743 | Oral cavity and pharyngeal cancer |
| BRCA | cis | rs3730682 | 1 | rs115515961 | chr18:51836253 | POLI | chr18:51795849-51824602:+ | 0.14 | 4.52 | 6.99E-6 | Psoriasis |
| BRCA | cis | rs60843830 | 1 | rs11553746 | chr2:272203 | SH3YL1 | chr2:218138-264810:- | -0.7 | -20.75 | 1.33E-80 | Spherical equivalent (joint main effects and education interaction) |
| BRCA | cis | rs12748152 | 1 | rs11555809 | chr1:27216669 | GPATCH3 | chr1:27216980-27226962:- | 0.23 | 3.97 | 7.71E-5 | HDL cholesterol;Triglycerides;LDL cholesterol |
| BRCA | cis | rs1853207 | 1 | rs11568732 | chr10:96521574 | C10orf129 | chr10:96953957-96988685:+ | 0.25 | 4.51 | 7.28E-6 | Blood metabolite levels |
| BRCA | cis | rs17401966 | 1 | rs11576866 | chr1:10414432 | PGD | chr1:10459085-10480200:+ | 0.23 | 6.35 | 3.22E-10 | Hepatocellular carcinoma |
| BRCA | cis | rs11799420 | 1 | rs11577073 | chr1:171716724 | VAMP4 | chr1:171669298-171711214:- | -0.21 | -6.29 | 4.59E-10 | Hippocampal atrophy |
| BRCA | cis | rs11799420 | 1 | rs11577745 | chr1:171720909 | VAMP4 | chr1:171669298-171711214:- | 0.23 | 6.61 | 5.88E-11 | Hippocampal atrophy |
| BRCA | cis | rs11799420 | 1 | rs11578699 | chr1:171719769 | VAMP4 | chr1:171669298-171711214:- | 0.23 | 6.41 | 2.2E-10 | Hippocampal atrophy |
| BRCA | cis | rs17401966 | 1 | rs11578788 | chr1:10422958 | PGD | chr1:10459085-10480200:+ | 0.23 | 6.35 | 3.1E-10 | Hepatocellular carcinoma |